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目的分析极低出生体重儿真菌败血症早期临床特点,为早期诊断提供依据。方法对新生儿重症监护室(NICU)内17例确诊为真菌败血症的极低出生体重儿的临床资料进行回顾性分析。结果确诊患儿早期主要表现为呼吸暂停、反应差、呼吸急促,喂养不耐受,末梢循环灌注差、高血糖等。实验室检查主要血小板减少、CRP轻度升高,血清中1-3-β-D葡聚糖含量升高。结论极低出生体重儿如出现呼吸暂停、反应差、喂养不耐受、高血糖同时伴有血小板减少、血清中1-3-β-D葡聚糖升高应高度警惕真菌感染。
Objective To analyze the early clinical features of fungal sepsis in very low birth weight infants and provide basis for early diagnosis. Methods The clinical data of 17 children with very low birth weight who were diagnosed as fungal sepsis in neonatal intensive care unit (NICU) were analyzed retrospectively. Results Early diagnosis of early manifestations of apnea, poor response, shortness of breath, feeding intolerance, peripheral perfusion poor, high blood sugar and so on. Laboratory examination of the main thrombocytopenia, mild CRP increased serum levels of 1-3-β-D-glucan increased. Conclusions If there is apnea, poor response, feeding intolerance, hyperglycemia and thrombocytopenia in very low birth weight infants, the increase of 1-3-β-D-glucan in serum should be highly vigilant against fungal infection.