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１９９３年，Ｄａｈｌｂａｃｋ等［１］在家族性血栓症患者中发现活化蛋白Ｃ抵抗现象（ａｃｔｉｖａｔｅｄ ｐｒｏｔｅｉｎ Ｃ ｒｅｓｉｓｔａｎｃｅ，ＡＰＣＲ）；此后，在欧美国家静脉血栓性患者中发现凝血因子Ｖ（ＦＶ）基因第１６９１位的核苷酸Ｇ→Ａ点突变（即ＦＶ Ｌｅ
In 1993, Dahlback et al [1] found activated protein C resistance (APCR) in patients with familial thrombosis. Since then, coagulation factor V (FV) gene mutation 1691 has been found in venous thrombosis in European and American countries The nucleotide G → A point mutation (ie FV Le