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检测急性重量型肝炎患者肝组织中庚型肝炎病毒（ＨＧＶ） 的存在状况及探讨与发病的关系，采用免疫组化方法以抗－ ＨＧＶＮＳ５ 单克隆抗体对２６ 例急性重型肝炎患者尸检肝组织中的ＨＧＶ 等抗原进行了检测。结果显示２６ 例肝组织中检测出ＨＧＶ 阳性６ 例（２３ ．１ ％ ） 。ＨＧＶＮＳ５Ａｇ 阳性着色颗粒表达于残存的肝细胞浆内，阳性细胞呈片簇状分布于汇管区周围。６ 例中４例重叠有ＨＢＶ 或／ 和ＨＣＶ 感染，肝组织中ＨＢｓＡｇ 或／ 和ＨＣＶ ＮＳ３Ａｇ 检测阳性，另２ 例肝组织中仅见ＨＧＶ ＮＳ５ 抗原表达。ＨＧＶ 感染可能与一些急性重型肝炎发病有关。
To detect the presence of hepatitis G virus (HGV) in liver tissues of patients with acute severe hepatitis and its relationship with the pathogenesis. Immunohistochemistry was used to detect the expression of HGV in liver tissues of 26 patients with acute severe hepatitis by anti-HGVNS5 monoclonal antibody HGV and other antigens were detected. The results showed HGV positive in 26 cases of liver tissue in 6 cases (23.1%). HGVNS5Ag positive staining particles expressed in the remaining liver cytoplasm, positive cells were clustered around the portal area. Of the 6 cases, 4 cases were infected with HBV or / and HCV, and HBsAg or / and HCV NS3Ag in liver tissues were positive. Only HGV NS5 antigen was expressed in the other 2 cases. HGV infection may be related to the pathogenesis of some acute severe hepatitis.