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目的:研究乳腺癌胰岛素样生长因子I型受体(insulin-likegrowthfactor-Ireceptor,IGF-IR)的表达与乳腺癌各种病理学指标之间的相关性,从而评价乳腺癌IGF-IR表达与乳腺癌预后的关系。方法:收集120例乳腺癌组织、29例乳腺癌淋巴结转移癌组织病理石蜡块,用免疫组织化学的方法测定IGF-IR的表达,将表达程度分为0,1,2,3级,2和3级定义为高表达。回顾性研究120例乳腺癌病例的肿瘤大小、淋巴结转移、病理学类型、间质反应、肿瘤分化。将IGF-IR的表达与各项病理指标比较,运用统计学方法进行分析。结果:①IGF-IR在乳腺癌原发灶癌组织中的高表达高于淋巴结转移癌组织(χ2=5.042,P=0.025)。②低分化乳腺癌IGF-IR高表达比高分化乳腺癌IGF-IR高表达明显减少(χ2=8.955,P=0.003)。③IGF-IR的表达与患者的肿瘤大小、淋巴结转移、临床分期、病理类型、间质反应无相关性。结论:IGF-IR可能在乳腺癌抗转移方面扮演了一定的角色,IGF-IR的高表达可能与乳腺癌分化状态相关,提示较好的预后。
OBJECTIVE: To study the correlation between the expression of insulin-like growth factor-receptor (IGF-IR) and various pathological parameters in breast cancer, so as to evaluate the correlation between the expression of IGF-IR and breast Cancer prognosis. Methods: 120 cases of breast cancer tissues and 29 cases of breast cancer with lymph node metastasis were collected for pathological paraffin sections. The expression of IGF-IR was determined by immunohistochemical method. The expression levels were classified into grades 0, 1, 2 and 3, 2 and Level 3 is defined as high expression. A retrospective study of 120 cases of breast cancer tumor size, lymph node metastasis, pathological types, interstitial reaction, tumor differentiation. The expression of IGF-IR and various pathological indicators were compared, using statistical methods for analysis. Results: ① The expression of IGF-IR in primary breast cancer tissues was higher than that in lymph node metastases (χ2 = 5.042, P = 0.025). ② The high expression of IGF-IR in poorly differentiated breast cancer was significantly lower than that in well-differentiated breast cancer (χ2 = 8.955, P = 0.003). ③ The expression of IGF-IR had no correlation with tumor size, lymph node metastasis, clinical stage, pathological type and interstitial reaction. Conclusion: IGF-IR may play a role in anti-metastasis of breast cancer. The high expression of IGF-IR may be related to the differentiation status of breast cancer, suggesting a better prognosis.