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目的：探讨上皮性卵巢癌组织中血管内皮生长因子（ＶＥＧＦ）的表达及其临床意义。方法：以ＳＡＢＣ免疫组化分析法检测３７例上皮性卵巢癌组织中ＶＥＧＦ的表达。结果：上皮性卵巢癌、交界性卵巢肿瘤及良性肿瘤组织中ＶＥＧＦ阳性表达率分别为７２．９７％、６２．５０％及３８．４６％，恶性肿瘤及交界性肿瘤组织中ＶＥＧＦ表达率较良性肿瘤者明显增高（Ｐ＜０．０５），且前两者的ＶＥＧＦ强阳性表达率也较良性肿瘤者明显增高（Ｐ＜０．０５）。上皮性卵巢癌中ＶＥＧＦ阳性表达率与有淋巴结转移者密切相关（Ｐ＜０．０５）。ＶＥＧＦ表达率与卵巢癌的临床分期及病理分级未见显著相关性。结论：ＶＥＧＦ在上皮性卵巢癌的生长及转移中可能起着重要作用。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in epithelial ovarian cancer and its clinical significance. Methods: The expression of VEGF in 37 cases of epithelial ovarian cancer was detected by SABC immunohistochemical method. Results: The positive expression rate of VEGF in epithelial ovarian cancer, borderline ovarian tumor and benign tumor was 72.97%, 62.50% and 38.46%, respectively. The positive rate of VEGF in malignant and borderline tumor was higher The tumor was significantly higher (P <0.05), and the first two strong positive VEGF expression than benign tumors were significantly higher (P <0.05). The positive rate of VEGF expression in epithelial ovarian cancer is closely related to those with lymph node metastasis (P <0.05). There was no significant correlation between VEGF expression and clinical stage and pathological grade of ovarian cancer. Conclusion: VEGF may play an important role in the growth and metastasis of epithelial ovarian cancer.