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有研究表明ＡＣＥ基因（分ＤＤ、ＩＤ、ＩＩ三种基因型）与心血管疾病（如高血压、左心室肥大、心肌梗塞等）关系密切。为探讨ＡＣＥ基因多态性与高血脂的可能关系，在上海华山医院老干部体检中心体检者中抽取３１名高胆固醇患者和３４名血脂正常者作对照研究，利用对象的血凝块提取ＤＮＡ，经ＰＣＲ扩增和琼脂糖凝胶电泳检测其ＡＣＥ基因型。实验结果显示，患者组与对照组间ＡＣＥ基因型分布无显著性差异，等位基因频率也无显著性差异，结果提示ＡＣＥ基因与高血脂可能没有联系，等位基因Ｄ可能不是高血脂的一个潜在危险因素，但与样本量较小有关，有待于进一步研究。
Studies have shown that the ACE gene (DD, ID, II three genotypes) and cardiovascular disease (such as hypertension, left ventricular hypertrophy, myocardial infarction, etc.) are closely related. In order to investigate the possible relationship between ACE gene polymorphism and hyperlipidemia, 31 hypercholesterolemic patients and 34 normal subjects with lipids were selected from the physical examination center of veterans examination center in Huashan Hospital of Shanghai for DNA extraction. The ACE genotypes were detected by PCR amplification and agarose gel electrophoresis. The experimental results show that there is no significant difference in ACE genotype distribution between patients and control group, allele frequency was also no significant difference, the results suggest that ACE gene may not be associated with hyperlipidemia, allele D may not be a hyperlipidemia Potential risk factors, but related to the smaller sample size, remains to be further studied.