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目的观察比较缬沙坦联合氨氯地平、贝那普利治疗高血压的临床效果。方法选取医院收治的高血压患者156例作为研究对象,随机分为A、B、C组,每组52例。A组仅使用缬沙坦治疗;B组在A组治疗基础上给予氨氯地平治疗;C组在A组治疗基础上给予贝那普利治疗。观察3组患者使用不同药物治疗后的临床效果及不良反应发生情况。结果 B、C组治疗总有效率为94.23%、96.15%,高于A组的80.77%(P<0.05);B组与C组治疗总有效率比较差异无统计学意义(P>0.05)。3组不良反应发生率比较差异无统计学意义(P>0.05)。结论缬沙坦联合氨氯地平与缬沙坦联合贝那普利治疗高血压均有显著的临床效果。
Objective To compare the clinical effects of valsartan with amlodipine and benazepril in the treatment of hypertension. Methods A total of 156 hypertensive patients admitted to hospital were selected as study subjects and randomly divided into A, B and C groups, with 52 cases in each group. Group A was treated with valsartan only; Group B was treated with amlodipine on the basis of group A; Group C was treated with benazepril on the basis of group A. The clinical effects and adverse reactions of three groups of patients after treatment with different drugs were observed. Results The total effective rates of group B and group C were 94.23% and 96.15%, respectively, which were higher than those of group A (80.77%, P <0.05). There was no significant difference between group B and group C (P> 0.05). The incidence of adverse reactions in the three groups showed no significant difference (P> 0.05). Conclusion Valsartan combined with amlodipine and valsartan combined with benazepril in the treatment of hypertension have significant clinical effect.