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在我国1970～1975年间,临床曾广泛应用以东莨菪碱为主的中药麻醉(据统计约有十五万例)。这种麻醉的基本特点是使意识消失而呈麻醉状态。为了对其生理机制进行深入的分析,我们观察了东茛菪碱对家兔皮层神经元自发放电的影响。 实验方法 实验共用35只成年家兔,体重在2～2.5kg,以1％氯醛糖和10％乌拉坦混合液麻醉(5ml/kg),按常规做气管插管和延髓池引流术,在头顶相当于皮层感觉运动区钻直径4mm的圆孔,剪除脑膜后,用4％琼脂将钻孔封闭。待动物清醒,静
In our country from 1970 to 1975, the clinical use of scopolamine-based traditional Chinese medicine anesthesia (according to statistics, about 150,000 cases). The basic feature of this anesthesia is the loss of consciousness and anesthesia. In order to analyze its physiological mechanism in depth, we observed the effect of scopolamine on spontaneous firing in rabbit cortical neurons. Experimental Methods A total of 35 adult rabbits were enrolled in this study. The body weight was 2 ~ 2.5 kg. The rats were anesthetized (1 ml) with 1% chloralose and 10% urethane mixture (5 ml / kg) Head equivalent to the cortical area of motion drilling 4mm in diameter hole, cut the meninges, the hole closed with 4% agar. When the animals awake, quiet