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乙型肝炎疫苗的免疫效果虽已证实,但健康成人接种疫苗后的免疫力持续时间尚不清楚。作者观察了245名已接种疫苗3年的医院职工的抗-HBs水平,用Abbott酶联免疫测定试剂盒检测抗-HBs水平,低于10mIU/ml者为阴性。结果有93人(38%)抗-HBs阴性,多见于年龄大、体格指数(体重/身高~2)较高、吸烟和患病者。其中有71人随机皮内接种2μg(36人)或三角肌接种20μg(35人)疫苗。 1个月后检测抗-HBs。皮内组检测的33人中有25人产生抗-HBs,肌肉组32人中有25人抗-HBs阳转。两组抗体水平相似,对加强接种无应答仅与年龄较大和体格指数较高
Although the immune effect of hepatitis B vaccine has been confirmed, the duration of immunity of healthy adults after vaccination is not yet clear. The authors looked at the anti-HBs levels in 245 hospitalized workers who had been vaccinated for 3 years. Anti-HBs levels were measured using the Abbott enzyme-linked immunoassay kit, and were below 10 mIU / ml. Results 93 (38%) were negative for anti-HBs and more common in older adults with higher body mass index (weight / height ~ 2), smoking and illness. Of these, 71 were vaccinated intradermally with 2 μg (36) or deltoid inoculated with 20 μg (35 doses) of the vaccine. Anti-HBs were tested after 1 month. Twenty-five out of 33 patients in the intradermal group developed anti-HBs, and 25 in 32 patients in the intramuscular group developed anti-HBs positive. Antibody levels were similar in both groups, with no response to booster vaccination only with older and higher body mass index