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选择49例非何杰金淋巴瘤和小细胞肺癌等患者，采用常规CHOP和CAV方案进行治疗。定期用SPECT检测患者左心功能，评价阿霉素（ADM）对心肌的毒性作用。结果表明，化疗前后EF（射血分数）、PER（高峰射血率）和PFR（高峰充盈率）值比较，差别有显著性（P＜0.05）；体内的ADM累积量愈大，EF、PER和PFR值下降愈大，并以PFR变化最敏感。提示SPECT心功能测定是评价患者ADM心肌毒性的敏感、适用的方法。
Forty-nine patients with non-Hodgkin’s lymphoma and small-cell lung cancer were selected and treated with routine CHOP and CAV regimens. The left ventricular function was regularly detected by SPECT and the toxicity of adriamycin (ADM) to myocardium was evaluated. The results showed that the difference of EF, PER and PFR before and after chemotherapy was significant (P <0.05). The greater the cumulative amount of ADM in vivo, the higher the EF, PER And the PFR value decreased more, and most sensitive to PFR changes. Tip SPECT cardiac function test is to evaluate the sensitivity of patients with ADM myocardial toxicity, the applicable method.