Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism?

• 作 者: Elisa Piscianz Liza Vecchi Bru
• 机 构: DepartmentofMedicine,InstituteforMaternalandChildHealth-IRCCS“BurloGarofolo”
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2019年4期
• 关键词: CHOLESTEROL inflammation apoptosis AUTOPHAGY NEURONS INHERITED disease NECROPTOS
• 基金项目: a grant from the Institute for Maternal and Child Health–Istituto di Ricovero e Cura a Carattere Scientifico“Burlo Garofolo”–Trieste,Italy(RC 24/2017,to AT).

The balance of autophagy,apoptosis and necroptosis is crucial to determine the outcome of the cellular response to cholesterol dysregulation.Cholesterol plays a major role in regulating the properties of cell membranes,especially as regards their fluidity