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目的:观察金水宝胶囊联合前列地尔注射液治疗早期糖尿病肾病(DN)的临床疗效。方法:将60例DN患者随机分为对照组及治疗组各30例,对照组予降压降糖降脂等西药常规对症支持治疗,同时配合用前列地尔治疗,治疗组在对照组治疗基础上加用金水宝胶囊治疗。治疗2周后观察比较两组疗效,测定各组尿素氮(BUN)、肌酐(Scr)和尿白蛋白排泄率(UAER)。结果:总有效率治疗组为83.33%,对照组为53.33%,两组比较差异有统计学意义(P<0.05);两组治疗后BUN、Scr、UAER均较治疗前明显下降,差异有统计学意义(P<0.05);治疗组BUN、Scr和UAER较对照组下降更明显,差异有统计学意义(P<0.05)。结论:金水宝胶囊联合前列地尔注射液治疗早期DN患者疗效确切,值得临床推广应用。
Objective: To observe the clinical efficacy of Jinshuibao capsule combined with alprostadil injection in the treatment of early diabetic nephropathy (DN). Methods: Sixty patients with DN were randomly divided into control group and treatment group, with 30 cases in each group. The control group was given conventional antihypertensive, hypoglycemic and lipid-lowering drugs and other conventional symptomatic and supportive therapy. Meanwhile, the treatment group was treated with alprostadil, On the use of Jin Shui Bao capsule treatment. After 2 weeks of treatment, the curative effects of both groups were observed and compared. The levels of BUN, Scr and UAER in each group were measured. Results: The total effective rate was 83.33% in the treatment group and 53.33% in the control group, with significant difference between the two groups (P <0.05). The BUN, Scr and UAER in both groups were significantly lower than those before treatment (P <0.05). The levels of BUN, Scr and UAER in the treatment group decreased more significantly than those in the control group, with statistical significance (P <0.05). Conclusion: Jinshuibao capsule combined with alprostadil injection in the treatment of patients with early DN is effective and worthy of clinical application.