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目的探讨支气管肺泡灌洗液(BALF)中腺苷脱氨酶(ADA)浓度对肺结核诊断的临床价值。方法 74例疑似肺结核患者,在行纤维支气管镜检查时留取BALF,采用酶法测定BALF其中的ADA浓度。74例患者根据最终确诊结果分为两组:结核组33例,非结核组41例。结果结核组BALF中ADA平均浓度为(20±3)U/L,非结核组为(4±2)U/L,前者明显高于后者,两者差异有统计学意义(P<0.01)。结论检测BALF中ADA浓度对肺结核具有很高的诊断和鉴别诊断价值。
Objective To investigate the clinical value of adenosine deaminase (ADA) in bronchoalveolar lavage fluid (BALF) in the diagnosis of pulmonary tuberculosis. Methods Totally 74 patients with suspected pulmonary tuberculosis were enrolled in this study. BALF was collected during bronchoscopy and the concentration of ADA in BALF was determined by enzymatic method. According to the final diagnosis, 74 patients were divided into two groups: 33 cases in tuberculosis group and 41 cases in non-tuberculosis group. Results The average concentration of ADA in BALF was (20 ± 3) U / L in tuberculosis group and (4 ± 2) U / L in non-tuberculosis group, the former was significantly higher than the latter (P <0.01) . Conclusion The detection of ADA in BALF has a high diagnostic and differential diagnostic value for pulmonary tuberculosis.