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目的探讨新疆乌鲁木齐市女性高尿酸血症发病情况及与血糖、血脂水平关系。方法调查乌鲁木齐市791名女性体检者,检测血尿酸、空腹血糖、血脂等指标,选择191例高尿酸血症患者为病例组,同期346名健康女性作为对照组,进行病例对照研究。结果 791名女性研究对象中,高尿酸血症检出人数191例,检出率为24.15%,女性血尿酸平均值及高尿酸血症检出率在各年龄段分布差异有统计学意义(P<0.05);血尿酸值随年龄增高有所增加,≥60岁年龄组血尿酸值最高(327.23±88.24)μmol/L,高尿酸血症检出率以50～59岁年龄段最高为45.21%;女性绝经前后血尿酸水平(272.35±78.96),(317.64±80.45)μmol/L比较差异有统计学意义(P<0.05);高尿酸血症组血糖、胆固醇及甘油三酯水平均明显高于对照组(P<0.05)。结论女性在不同年龄段尿酸平均值及高尿酸血症患病率有明显差异,随着年龄增加,高尿酸血症的患病率有升高趋势。女性高尿酸血症与血糖、甘油三脂(TG)、总胆固醇(TC)、体质指数(BM I)呈明显正相关,绝经后的女性是高脂血症和高尿酸血症的易发人群。
Objective To investigate the incidence of hyperuricemia and its relationship with blood glucose and blood lipid in Urumqi, Xinjiang Uygur Autonomous Region. Methods A total of 791 female physical examiners in Urumqi were enrolled in this study. Serum uric acid, fasting blood glucose, blood lipids and other indexes were detected. 191 cases of hyperuricemia were selected as case group and 346 healthy women were selected as control group. Case-control study was conducted. Results Among the 791 female subjects, the number of hyperuricemia was detected in 191 cases with a detection rate of 24.15%. The average prevalence of serum uric acid and the rate of hyperuricemia among women were statistically significant (P <0.05). The serum uric acid value increased with age, the highest serum uric acid value was (327.23 ± 88.24) μmol / L in ≥60 years old group, and the highest detection rate of hyperuricemia was 45.21% (272.35 ± 78.96) and (317.64 ± 80.45) μmol / L, respectively (P <0.05). The levels of blood glucose, cholesterol and triglyceride in the hyperuricemia group were significantly higher than those in the hyperuricemia group Control group (P <0.05). Conclusion The prevalence of uric acid and hyperuricemia in women at different ages are significantly different. With the increase of age, the prevalence of hyperuricemia is on the rise. Female hyperuricemia was positively correlated with blood glucose, triglyceride (TG), total cholesterol (TC), body mass index (BMI), and postmenopausal women were susceptible to hyperlipidemia and hyperuricemia .