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随访应用庆大霉素及硫酸链霉素治疗严重梅尼埃病47例的前庭功能状态。其中以庆大霉素鼓室注射25例,2例分别于治疗后5、7个月眩晕复发;以硫酸链霉素外半规管灌注19例,2例分别于治疗后5、6个月眩晕复发;以硫酸链霉素肌注3例,1例于治疗后10个月复查,发现前庭功能恢复。此5例ENG检查示眼震持续时间恢复平均41秒。据此认为,人类前庭毛细胞受耳毒性抗生素损害后出现的前庭症状复发及功能恢复现象,推测可能为前庭毛细胞再生所致。但对此尚需获取更多的功能检查和形态学证据。
Follow-up application of gentamicin and streptomycin sulfate in the treatment of severe Meniere’s disease in 47 cases of vestibular function state. Among them, 25 cases were injected with gentamicin tympanum, 2 cases were vertigo recurrence 5 and 7 months after treatment, 19 cases were treated with streptomycin sulphate outside the semicircular canal, 2 cases had vertigo recurrence 5 and 6 months after treatment respectively. Streptomycin sulfate intramuscular injection in 3 cases, 1 case of 10 months after treatment review and found that the vestibular function recovered. The five ENG examinations showed an average nystagmus recovery of 41 seconds. Therefore, it is believed that the phenomenon of vestibular recurrence and functional recovery of human vestibular hair cells damaged by ototoxic antibiotics may be caused by the regeneration of vestibular hair cells. However, more functional tests and morphological evidence are needed for this.