人类精子DNA损伤与修复的研究进展

• 作 者: 王伟明 董毅飞 张昌军
• 机 构: 湖北医药学院附属人民医院生殖医学中心,
• 出 处: 中国优生与遗传杂志
• 发表日期: 2015年05期
• 关键词: Sperm DNA damage Repair

人类精子DNA是遗传信息的载体。其损伤会导致胚胎发育中断或自然流产,自然受孕率下降,产生先天性畸形儿等。一般认为精子DNA损伤与精子发生过程中的核蛋白组型转换异常、氧化应激、细胞异常凋亡、外界刺激等有关。目前,人们普遍认为发育成熟的精子丢失了DNA损伤修复能力,精子DNA损伤后主要依赖于受精卵的修复系统修复。

Human sperm DNA is the carrier of genetic information. The damage can lead to an interruption of embryonic development or spontaneous abortion, a decrease in the rate of natural conception, birth of congenital malformations, and the like. Generally believed that sperm DNA damage and spermatogenesis in the process of abnormal nuclear protein type conversion, oxidative stress, abnormal cell apoptosis, external stimuli and so on. At present, it is generally believed that mature sperm loses the ability of DNA damage repair, and sperm DNA damage mainly relies on the repair of the repair system of fertilized eggs.