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目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)与高血压的相关性。方法按照睡眠资料和24 h血压资料,分为单纯高血压组与合并OSAS高血压组,口服药物治疗4周,比较治疗前后血压变化,OSAS组降压效果差的患者同时接受持续气道正压(CPAP)治疗,观察血压控制情况。结果 30例单纯高血压患者,常规药物降压治疗4周后,血压较治疗前明显下降(P<0.05);OSAS组药物治疗前后无明显变化,再同时用CPAP治疗4周后晨起血压明显下降。结论合并有OSAS的高血压患者多为难治性,单纯降压药物治疗效果欠佳,需要同时应用CPAP治疗。
Objective To investigate the relationship between obstructive sleep apnea syndrome (OSAS) and hypertension. Methods According to the sleep data and 24 h blood pressure data, the patients were divided into simple hypertension group and OSAS hypertension group. Oral medication was used for 4 weeks. The changes of blood pressure before and after treatment were compared. Patients with poor antihypertensive efficacy in OSAS group received continuous positive airway pressure (CPAP) treatment, observation of blood pressure control. Results In 30 patients with hypertension, the blood pressure decreased significantly after 4 weeks of treatment with conventional drugs (P <0.05). No significant changes were observed in the OSAS group before and after treatment, and the morning blood pressure was significantly decreased after 4 weeks of treatment with CPAP. Conclusions Hypertensive patients with OSAS are mostly intractable. The treatment with simple antihypertensive drugs is ineffective and needs CPAP treatment.