马尔尼菲青霉病不同类型病变中免疫反应观察

• 作 者: 马韵 邓卓霖 罗虹
• 出 处: 广西医科大学学报
• 发表日期: 1994年04期
• 关键词: 马尔尼菲青霉病 免疫反应 细胞免疫 免疫功能状态 体液免疫 真菌感染 抗真菌免疫 人体免疫系统 巨噬细胞 播散型

选用２组病变类型不同的６例马尔尼菲青霉病人病变组织，采用免疫组化ＰＡＰ法，观察病变组织中ｌ８淋巴细胞、巨噬细胞、ＩｇＧ、ＩｇＭ、乙等免疫指标。结果发现马尔尼菲青霉病的病变类型取决于机体的免疫功能状态，人体抗马尔尼菲青霉免疫以细胞免疫为主，组织中Ｔ细胞的存在对于杀灭真菌、局限病变具有积极意义；体液免疫特别是特异性抗体的出现除具有促进细胞免疫功能外，可能也是脓肿成因之一。

Two groups of lesions with different types of lesions of Penicillium marneffei were selected. Immunohistochemical PAP method was used to observe the immune indexes of lymphocytes, macrophages, IgG, IgM and B in the diseased tissues. The results showed that the type of Penicillium marneffei disease depends on the immune status of the body, human anti-Penicillium marneffei immune cell-based immunity, the presence of tissue T cells for the destruction of fungi, localized disease has a positive meaning; Humoral immunity, especially the emergence of specific antibodies in addition to promoting cellular immune function, may also be one of the causes of abscess.