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70年代中期出现的单克隆抗体技术,使免疫化学获得极大进展。有可能应用于肿瘤以及病毒性疾病、免疫异常性疾病的临床诊断治疗。人们已知天然的免疫系统包含着难以计数的针对各种抗原的抗体,要想取得对某一特异性抗原的单一抗体十分困难。常规的方法是用各种抗原吸收血清中其他不需要的抗体,当获得特异性抗体时,其含量已经少得无法应用。肿瘤抗原是弱抗原,用传统的制备抗体的方法就更难以获得足量的特异性抗体。受抗原
The monoclonal antibody technology that emerged in the mid-1970s made immense advances in immunochemistry. It may be applied to the clinical diagnosis and treatment of tumors, as well as viral diseases and immune abnormalities. It is known that the innate immune system contains countless antibodies against various antigens, making it difficult to obtain a single antibody to a specific antigen. The conventional method is to use various antigens to absorb other unwanted antibodies in the serum, and when the specific antibodies are obtained, the content thereof has become scarcely available. Tumor antigens are weak antigens, and it is even more difficult to obtain a sufficient amount of specific antibodies using the traditional methods of preparing antibodies. By antigen