论文部分内容阅读
采用ＦＣＭ检测脑梗塞患者（１６例腔梗，１８例大面积梗塞）颈内静脉（Ａ）和肘静脉（Ｂ）的血小板ＧＭＰ－１４０，ＧＰ５３和ＧＰⅡｂ／Ⅲａ。结果：脑梗塞组Ａ和Ｂ血中三种ＧＰ阳性表达率均明显高于非脑血管疾病（ＣＶＤ）组和健康组Ｂ血（Ｐ＜０．０１～０．００１）；脑梗塞组Ａ血明显高于同组Ｂ血（Ｐ＜０．０５～０．００５），Ａ／Ｂ比值为１．２４～２．５２，而非ＣＶＤ组Ａ与Ｂ血之间阳性率无显著差异，Ａ／Ｂ比值≤１．０６；大面积梗塞组Ａ血阳性率高于腔梗组Ａ血（Ｐ＜０．０５），但两组Ｂ血无显著差异。提示脑梗塞急性期血小板主要在脑循环中活化，测定Ａ血指标较测定Ｂ血更能敏感地反映脑梗塞时血小板的活化程度和功能状态。
Platelet GMP-140, GP53 and GPIIb / IIIa were detected by FCM in the internal jugular vein (A) and the cubital vein (B) in patients with cerebral infarction (16cases infarcts, 18cases of large infarcts) Results: The positive rates of three GPs in A and B blood of cerebral infarction group were significantly higher than those of non-cerebrovascular disease (CVD) group and healthy group B (P <0.01-0.001) (P <0.05-0.005), the A / B ratio was 1.24-2.52, while there was no significant difference in the positive rate of A / B between non-CVD group and A / B ratio≤1.06; The positive rate of blood A in large area infarction group was higher than that of blood in group A (P <0.05), but there was no significant difference between the two groups. It is suggested that platelets in the acute stage of cerebral infarction are mainly activated in the cerebral circulation. The determination of A blood index is more sensitive than the measurement of B blood platelet to reflect the degree of platelet activation and functional status in cerebral infarction.