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化疗控制绒毛膜癌的效果逐渐增加,即使肺部有损害,以冲击式化疗常能缓解。若肺绒癌患者hCG水平持续升高,无他处转移,以及有辅加化疗禁忌症时,手术切除病灶或可有用,但肺内活性瘤灶的探查可能有一定困难,特别是患者肺内有疤痕时。妊娠性绒毛膜癌的复发,可由hCGβ-亚单位水平升高证明,但手术切除定位不容易。虽则放射标记多克隆抗体中hCG抗体已被用于探查人和动物的绒毛膜癌灶,但还不能探查出肺部的隐性绒癌。单克隆抗体用于放射免疫荧光图优于多克隆试剂。最近作者以~(131)I标记单克隆抗体,成功地探查出临床肺部隐性绒癌。本文报导1例29岁妇女,有4年绒癌史,因hCG复升而住入Michigan大学医疗中心。患者于1981年自然流产后2月子宫破裂出血行子宫切除
Chemotherapy to control the effect of choriocarcinoma gradually increased, even if the lung damage, with impact chemotherapy can often relieve. If the level of hCG in patients with lung cancer continued to rise, no other place metastasis, and additional chemotherapy with contraindications, surgical resection of the lesion may be useful, but exploration of the lung may be some of the active tumor lesions, especially in patients with lung When there are scars. Pregnancy choriocarcinoma recurrence, hCGβ-subunit may be elevated, but surgery is not easy to locate. Although hCG antibodies in radiolabeled polyclonal antibodies have been used to probe chorionic foci in humans and animals, it has not yet been possible to detect the presence of cryptogenic choriocarcinoma in the lungs. Monoclonal antibodies for radioimmunofluorescence are superior to polyclonal reagents. Recently, the authors used ~ (131) I labeled monoclonal antibody to successfully probe clinical lung implicit choriocarcinoma. This article reports a 29-year-old woman with a 4-year history of choriocarcinoma who was admitted to the University of Michigan Medical Center due to a hCG rise. Hysterectomy was performed in patients with uterine rupture in February after spontaneous abortion in 1981