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氟化物是常见的工业污染物之一。高浓度氟污染可否造成遗传危害尚无定论。本文应用BALB/C小鼠骨髓嗜染红细胞微核试验及蚕豆根尖微核试验对氟化钠、氟化钙的染色体毒作用进行了研究。结果表明,30mg/kg氟化钠腹腔注射BALB/C小鼠可诱发微核率明显升高(6.2±1.3‰,P<0.01),且有一定剂量及时间-反血关系,氟化钠(10～
Fluoride is one of the common industrial pollutants. Whether the high concentration of fluorine pollution can cause genetic damage is inconclusive. In this study, the chromosomal toxicities of sodium fluoride and calcium fluoride were studied using the micronucleus test of BALB / C mouse bone marrow erythrocytes and the micronucleus test of Vicia faba root tips. The results showed that the intraperitoneal injection of 30mg / kg sodium fluoride induced a significant increase in the micronucleus rate in the BALB / c mice (6.2 ± 1.3 ‰, P <0.01), and some dose and time- 10 ~