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[目的]探讨结直肠癌患者血清长链非编码RNA(LncRNA)H19表达水平与其预后的相关性.[方法]选取2013年1月至2015年12月于本院行根治术+辅助化疗的86例结直肠癌患者为研究对象(观察组),选取同期于本院健康体检的90例志愿者对照组.采用qRT-PCR检测两组血清LncRNA H19表达水平,分析观察组患者血清LncRNA H19表达水平与化疗后效果的相关性.[结果]qRT-PCR结果显示,观察组术前血清LncRNA H19水平为(1.63±0.35)显著高于对照组(1.00±0.11),差异具有统计学意义(t=16.259,P<0.01).以观察组血清LncRNA H19表达水平的中位数2.03为临界值,将患者分为高表达组和低表达组,两组各43例.高表达组肿瘤最大径、低分化、淋巴结转移、侵及浆膜、Ⅲ~Ⅳ期的比例、术前CEA水平显著高于低表达组,差异有统计学意义(P0.05).高表达组患者中位总生存时间(OS)、无进展生存期(PFS)分别为33.6个月、22.9个月显著低于低表达组的55.8个月、43.3个月,差异均有统计学意义(P<0.05).[结论]结直肠癌患者的血清LncRNA H19水平高表达者的生存状况较差,术后化疗的敏感性更低,但与化疗耐受性未见明显相关性.“,”[Objective]ToinvestigatethecorreLationbetweentheexpressionofserumLong-chainnon-coding RNA (LncRNA)H19andprognosisinpatientswithcoLorectaLcancer.[Methods]Eighty-sixpatientswithcoLorectaL cancerwhounderwentradicaLoperationandadjuvantchemotherapyinourhospitaLfromJanuary2013toDecember 2015wereseLectedasthestudysubjects(observationgroup).90voLunteerswhounderwentphysicaLexamination inourhospitaLduringthesameperiodwereseLectedasthecontroLgroup.TheexpressionLeveLofLncRNA H19in serumofthetwogroupswasdetectedbyqRT-PCR,andthecorreLationbetweentheexpressionLeveLofLncRNA H19inserum oftheobservationgroupandtheeffectofchemotherapy wasanaLyzed.[ResuLts]TheresuLtsof qRT-PCRshowedthattheLeveLofserumLncRNA H19intheobservationgroupwas (1.63±0.35)significantLy higherthanthatinthecontroLgroup(1.00± 0.11),andthedifferencewasstatisticaLLysignificant(t=16.259,P<0.01).ThecriticaLvaLue2.03wassetasthemedianLeveLofserumLncRNA H19expressionintheobservation group,andthepatientsweredividedintotwogroups:highexpressiongroupandLowexpressiongroup,43casesin eachgroup.Themaximumdiameter,Lowdifferentiation,Lymphnodemetastasis,invasionofserosa,thepropor-tionofstageⅢ~ⅣandpreoperativeCEALeveLinthehighexpressiongroupweresignificantLyhigherthanthose intheLowexpressiongroup (P0.05).ThemediantotaLsurvivaLtime (OS)andpro-gression-freesurvivaL(PFS)inthehigh-expressiongroupwere33.6monthsand22.9monthsrespectiveLy,which weresignificantLyLowerthanthoseintheLow-expressiongroup (55.8 monthsand43.3 months),withstatisticaL significance(P<0.05).[ConcLusion]ThesurvivaLofpatientswithhighexpressionofserumLncRNA H19incoLo-rectaLcancerispoor,andthesensitivityofpost-operativechemotherapyisLower,butthereisnosignificantcorre- LationwithchemotherapytoLerance.