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目的:了解血浆脂蛋白(a)[(Lp(a)]、载脂蛋白AI(apoAI)、载脂蛋白B(apoB)水平在冠心病患者的变化,观察Lp(a)与冠状动脉粥样硬化程度之间的关系。方法:将冠心病患者498例按疾病发展进程进行分类,即稳定型心绞痛207例,不稳定型心绞痛184例,心肌梗死107例。另设健康对照组150例。同时以免疫透射比浊法对血浆中Lp(a),apoAI,apoB水平进行检测。结果:冠心病患者血中Lp(a)、apoB水平明显高于健康对照组P<0.05。结果表明,随着冠状动脉粥样硬化的严重程度逐步增加,血中Lp(a)、apoB逐步上升,两者呈正相关,r=0.4596,P<0.05。结论:Lp(a)与冠状动脉粥样硬化程度有着密切联系,是一个独立的致冠心病危险因子。
Objective: To investigate the changes of plasma lipoprotein (a) [Lp (a)], apolipoprotein AI (apoAI) and apolipoprotein B (apoB) in patients with coronary heart disease Sclerosis.Methods: 498 patients with coronary heart disease were classified according to the disease progression process, including 207 cases of stable angina pectoris, 184 cases of unstable angina pectoris, 107 cases of myocardial infarction.Another 150 cases of healthy control group The levels of Lp (a), apoAI and apoB in plasma were detected by immunoturbidimetry.Results The levels of Lp (a) and apoB in blood of patients with coronary heart disease were significantly higher than those in healthy controls (P <0.05) .The results showed that with the increase of The severity of coronary atherosclerosis gradually increased, and the levels of Lp (a) and apoB in the blood rose gradually, with a positive correlation (r = 0.4596, P <0.05) .Conclusion: Lp (a) is closely related to the degree of coronary atherosclerosis Contact, is an independent risk factor for coronary heart disease.