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缺血后处理是指心肌发生缺血后,在长时间的再灌注之前进行数次短暂再灌注/缺血的循环,是近年提出的一种新的减轻再灌注损伤的方法,赵志清等首先在犬的在体缺血再灌模型中,发现缺血后处理可以缩小心肌梗死范围,具有心肌保护作用,Galagudza等在鼠的离体缺血再灌模型中证实缺血后处理可降低缺血/再灌注损伤引起的心室颤动,有抗心律失常作用,Staat等在临床上证实了缺血后处理的心肌保护作用。缺血后处理的保护机制可能与氧自由基的生成减少、内源性活性物质的释放、膜通道功能状态的变化和蛋白激酶的活化有关,现就缺血后处理的发现、机理和临床应用作一简要综述。
Ischemic postconditioning refers to a few reperfusion / ischemia cycles that occur shortly after a long period of reperfusion after myocardial ischaemia, and is a new method of reducing reperfusion injury that has been proposed in recent years. Zhao et al. In canine ischemia-reperfusion model, it was found that ischemic postconditioning can reduce the myocardial infarction range, with myocardial protection, Galagudza and other in vitro ischemia-reperfusion model in mice confirmed that ischemic postconditioning can reduce ischemia / Reperfusion injury caused by ventricular fibrillation, anti-arrhythmic effect, Staat et al clinically confirmed myocardial ischemic postconditioning. The protective mechanism of ischemic postconditioning may be related to the reduction of oxygen free radicals generation, the release of endogenous active substances, the change of membrane channel functional status and the activation of protein kinases. The discovery, mechanism and clinical application of ischemic postconditioning Make a brief overview.