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真核细胞中的内质网是蛋白质合成、翻译和转运的场所,当内质网稳态被打破,出现蛋白质折叠障碍或错误折叠,并导致蛋白质过度积累时,便会引发内质网应激反应,即未折叠蛋白反应。大量的研究表明,内质网应激与2型糖尿病的病理特征有一定的关系,而转录激活因子6通路作为未折叠蛋白反应中3条信号通路之一,调控着蛋白质的重折叠过程,对缓解内质网应激以及在糖脂代谢和胰岛素敏感性方面起着重要作用。简介内质网应激反应及相关信号通路和转录激活因子6,着重综述转录激活因子6在肝脏糖脂代谢和胰岛素抵抗中的作用及相应机制,探讨其成为抗2型糖尿病药物新靶点的可能性,为抗2型糖尿病药物的研发提供新思路。
The endoplasmic reticulum in eukaryotes is where proteins are synthesized, translated, and transported. Endoplasmic reticulum stress is triggered when the homeostasis of the endoplasmic reticulum is broken, protein folding disorders or misfolding occur, and protein over-accumulation occurs The reaction, ie the unfolded protein reaction. A large number of studies have shown that endoplasmic reticulum stress has a certain relationship with the pathological features of type 2 diabetes. The transcriptional activator 6 pathway, as one of the 3 signaling pathways in the unfolded protein, regulates protein refolding. Relieve endoplasmic reticulum stress and play an important role in glycolipid metabolism and insulin sensitivity. Introduction Endoplasmic reticulum stress response and related signal pathways and transcriptional activators 6, focusing on the role of transcriptional activator 6 in liver glucose and lipid metabolism and insulin resistance and its corresponding mechanisms, to explore its become a new target of anti-type 2 diabetes drug Possibility of providing new ideas for the development of anti-type 2 diabetes drugs.