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大约50%活动性慢性中耳炎粘脓性分泌物中可培养出需氧与厌氧菌的混合菌丛。为了探讨厌氧菌的作用,作者们选择了33例在4周内未行全身或局部抗菌治疗的慢性活动性中耳炎成年患者,洗耳后于手术显微镜下检查,若中耳或乳突腔有恶臭性黄色粘脓及中耳粘膜发炎,即取分泌物培养。1周后复查,若该耳炎症仍活动且培养出厌氧菌,即选作本组研究对象。按以下方案给药:方案1用灭滴灵(Metronidazole)200mg,日三次,共2～4周。方案2用灭滴灵2.4 g,立即给1次或2次。方案3用灭滴灵400 mg,日三次,共2周,并加先锋霉素或复方新诺明。结果:4例因未能随访而剔除,余29例。治疗前培养有G(-)厌氧杆菌者33株,G(+)厌氧球菌7株、需氧菌35株,平均每例厌氧菌株数为1.4,需氧菌株为1.2。能坚持治疗者
About 50% of active chronic otitis media can produce aerobic and anaerobic bacterial flora in mucopurulent secretions. In order to investigate the role of anaerobic bacteria, the authors selected 33 adult patients with chronic active otitis media who did not undergo systemic or topical antibacterial treatment within 4 weeks. After ear washing, they were examined under a surgical microscope. If the middle ear or mastoid cavity had Stenchy yellow pus and inflammation of the middle ear mucosa, that is, take secretions culture. 1 week after the review, if the ear inflammation is still active and cultured anaerobic bacteria, that is, selected for the study group. Administered according to the following scheme: Scheme 1 Metronidazole 200mg, three times a day, a total of 2 to 4 weeks. Option 2 with metronidazole 2.4 g, immediately give 1 or 2 times. Option 3 metronidazole 400 mg, three times a day, a total of 2 weeks, and add cephalosporins or cotrimoxazole. Results: 4 cases were excluded due to failure to follow up, the remaining 29 cases. Before treatment, there were 33 strains of G (-) anaerobic bacteria, 7 strains of G (+) anaerobic bacteria and 35 aerobic bacteria, with an average number of anaerobic strains of 1.4 and an aerobic strain of 1.2. Can adhere to the treatment