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尽管生长抑制基因(ING)家族被发现不久,但研究认为它是公认的抑癌基因进化家族的一部分。ING1基因是这个家族的第一个成员,编码几个不同的mRNA变异体,产生一个蛋白家族。目前研究最多的蛋白亚型是p33ING1b,它与限制细胞生长和增殖、凋亡、肿瘤的非锚定生长、细胞衰老、维持基因组稳定和调节细胞周期调节点有关。ING1基因在肿瘤中很少发生突变,尽管p33ING1b的亚细胞位置可能影响它的功能。p33ING1b从胞核转移到胞质可能失去正常的细胞功能,很可能是一些肿瘤发病机制的中枢环节。
Although the growth inhibitory (ING) family was discovered shortly after, the study concluded that it is a well-established family of tumor suppressor genes. The ING1 gene is the first member of this family and encodes several different mRNA variants to produce a protein family. The currently most studied protein subtype is p33ING1b, which is involved in the regulation of cell growth and proliferation, apoptosis, non-anchored growth of tumors, cell senescence, maintenance of genomic stability and regulation of the cell cycle. The ING1 gene rarely mutates in tumors, although the subcellular location of p33ING1b may affect its function. P33ING1b transfer from the nucleus to the cytoplasm may lose the normal cell function, it is likely that some of the central mechanism of tumor pathogenesis.