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(一)用气泡流量計测定84只不麻醉雄兔的脑血流,頸动脉平均血压(BP)是107±17毫米汞柱,脑血流量(CBF)是142±35毫升/100克脑/分鐘,脑血管阻力(CVR)为0.80±0.24毫米汞柱/毫升血/100克脑/分鐘。在持續試驗2小时过程中比較稳定。 (二)吐酒石的作用:治疗量和三日疗法对兔脑血流无明显影响,靜脉和腹腔用藥40毫克/千克以上时,均呈現不同程度的CBF减慢和CVR增大。CVR主要反映脑血管口徑的变化,所以中毒剂量的吐酒石有收縮脑血管的作用。發生心律紊乱前,CBF已在逐漸减慢,而CVR正行加大。再繼續观察,当处于BP显著低、CBF显著慢、OVR显著大的状态时,心电圖也發現心律紊乱。 頸动脉注射吐酒石4微克以下对脑血流无影响,只有在極高的濃度(0.8毫克)时,發生CBF驟增,CVR頓时銳减,数分鐘后复原。 (三)靜脉注射二巯基丁二酸鈉0.25克/千克时,未發現对CBF和CVR的明显作用。而剂量加倍时則引起心律紊乱、CBF减慢和CVR加大。靜脉注射硫酸阿託品1毫克/千克时,有CBF减少和CVR增大的趋势。2毫克/千克时,CBF明显增多,CVR同时变小。 頸动脉注射二巯基丁二酸鈉4.8毫克或硫酸阿託品20微克后,均立卽出現CBF加快,CVR减小。
(A) Cerebral blood flow was measured in 84 non-anesthetized male rabbits using a bubble flow meter. The average carotid artery blood pressure (BP) was 107 ± 17 mmHg, and the cerebral blood flow (CBF) was 142 ± 35 ml / 100 g brain / Minute and a cerebrovascular resistance (CVR) of 0.80 ± 0.24 mmHg / ml blood / 100 g brain / minute. In the course of 2 hours of continuous test more stable. (B) spit tartar effect: the amount of treatment and three days on the rabbit cerebral blood flow no significant effect, intravenous and intraperitoneal administration of 40 mg / kg or more, showed varying degrees of CBF slowed down and increased CVR. CVR mainly reflects the changes in cerebrovascular caliber, so poisoning dose of tartar contraction of cerebral blood vessels. Prior to the occurrence of arrhythmia, CBF has been gradually slowed down, while the positive CVR increased. Continuing the observation, arrhythmia was also found in the electrocardiogram when BP was significantly lower, CBF significantly slower, and OVR significantly larger. Carotid Injecting Tartar 4 micrograms or less has no effect on cerebral blood flow, CBF surge occurs only at very high concentrations (0.8 mg), CVR suddenly decreases, and recovery occurs after a few minutes. (C) intravenous sodium dimercaptosuccinate 0.25 g / kg, no significant effect on CBF and CVR was found. Doubling the dose causes a heart rate disorder, slower CBF, and greater CVR. Intravenous injection of atropine sulfate 1 mg / kg, there is a decrease in CBF and CVR trend. At 2 mg / kg, CBF increased significantly and CVR decreased at the same time. After carotid artery injection of sodium dimercaptosuccinate 4.8 mg or 20 micrograms of atropine sulfate, both were 卽 CBF speed up, CVR decreased.