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本文用双盲对照法研究硫唑嘌呤治疗慢性非特异性溃疡性结肠炎30例,病变部位累及直肠及直肠以上。入院前需每日服强的松10毫克以上以控制症状,用药超过12周。入院后随机分为对照组和硫唑嘌呤(每日每公斤体重1.5毫克)治疗组,治疗观察半年。原强的松剂量按症状控制得好或不好,每2～3周调整剂量1次,减量或加量。对照组14例(男6例,女8例),平均年龄30.6岁(18～64岁),治疗组16例(男9例,女7例),平均年龄32.8岁(16～62岁)。对照组中有8例,治疗组中有11例,X线显示弥漫性结肠炎。治疗开始3周和结束前3周比较每日排便次数、一般状况、直肠窥镜及直肠粘膜活检所见。
In this paper, double-blind control study of azathioprine treatment of chronic non-specific ulcerative colitis in 30 cases, the lesion involving the rectum and rectum above. Prior to admission to daily doses of prednisone 10 mg or more to control the symptoms, medication for more than 12 weeks. After admission were randomly divided into control group and azathioprine (1.5 mg / kg body weight per day) treatment group, the treatment observed for six months. The original prednisone dose control by symptom well or not good, every 2 to 3 weeks to adjust the dose 1, reduction or dosage. Control group, 14 cases (6 males and 8 females), the average age of 30.6 years (18 to 64 years), the treatment group of 16 patients (9 males and 7 females), mean age 32.8 years (16 to 62 years old). There were 8 cases in the control group and 11 cases in the treatment group. X-ray showed diffuse colitis. The number of daily bowel movements, general condition, rectal speculum and rectal mucosal biopsy were compared at the beginning of the 3 weeks of treatment and 3 weeks before the end of the treatment.