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头孢三嗪(Ceftriaxone)对革兰氏阳性和革兰氏阴性菌(包括伤寒沙门氏菌)具有广谱抗菌活性,且半衰期长,成人为6.5～8.6小时,儿童为6.0～7.4小时。本研究对用头孢三嗪或氯霉素随机对照治疗儿童伤寒的疗效进行了比较。59例经细菌学证实的患儿随机分成两组。29例(男6例,女23例)接受头孢三嗪治疗。头孢三嗪用1％利多卡因稀释,每日1次,每次80mg/kg肌注,疗程5天。30例(男12例,女18例)接受氯霉素治疗,11服,每日50～100mg/kg,每6
Ceftriaxone has broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria, including Salmonella typhi, and has a long half-life of 6.5 to 8.6 hours in adults and 6.0 to 7.4 hours in children. This study compared the efficacy of a randomized controlled trial of ceftriaxone or chloramphenicol in the treatment of typhoid in children. 59 cases of bacteriologically confirmed children were randomly divided into two groups. 29 cases (6 males and 23 females) received ceftriaxone treatment. Ceftriaxone 1% lidocaine diluted 1 day, each 80mg / kg intramuscular injection, the course of treatment for 5 days. 30 cases (12 males and 18 females) received chloramphenicol treatment, 11 servings, 50 ~ 100 mg / kg daily, every 6