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正常女孩青春期成熟促性腺激素(GTH)对下丘脑促性腺激素释放激素(GnRH)反应形式有显著变化。在10岁以内FSH对GnRH的反应缓慢下降,青春期开始进一步减低。LH的反应在青春期前低,青春期急剧增加。对垂体GTH反应形式的这种反转无法解释,可能有一种特异性的下丘脑激素包含在FSH分泌的控制机理中。这种激素尚未确定,现反知有一种下丘脑释放激素控制FSH及LH的分泌。神经厌食症患者,体重低于正常时常有闭经,过去的研究证实厌食症病人GTH分泌与青春期前及早期青春期女孩者相似,LH基础水平低,24小时分泌情况无自发性夜间分泌的证据。低体重厌食患者对克罗米芬枸橼酸盐无反应,对GnRH的激素反应与青春期前相似。体重恢复后病人的血浆GTH增加,LH及FSH分泌情况成熟,与正常青
Normal girl adolescent mature gonadotropin (GTH) on the hypothalamic gonadotropin-releasing hormone (GnRH) response to the form of significant changes. FSH response to GnRH slowed down within 10 years of age and further decreased during adolescence. LH response in pre-puberty, a sharp increase in adolescence. This reversal of the form of the pituitary GTH response is unexplained and it is possible that a specific hypothalamic hormone is involved in the control of FSH secretion. This hormone has not yet been determined, now known to have a hypothalamic hormone release control FSH and LH secretion. Nerve anorexia patients, weight less than normal often amenorrhea, past studies confirmed that GTH secretion in anorexia patients and pre-adolescent girls and adolescent girls were similar, low level of LH, 24-hour secretion of spontaneous nocturnal secretion no evidence. Patients with low body weight anorexia did not respond to clomiphene citrate, and hormone responses to GnRH were similar to those before puberty. After recovery, the patient’s plasma GTH increased, LH and FSH secretion matured, and normal