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目的探讨乳酸菌阴道胶囊对妊娠中晚期外阴阴道假丝酵母菌病(VVC)患者不良妊娠结局的预防作用。方法将136例妊娠中晚期VVC患者随机分为联合组和对照组各68例。联合组患者予以乳酸菌阴道胶囊(0.25g/晚)及制霉菌素(50万IU/晚)联合阴道上药治疗(两药使用间隔4~6h);对照组患者予以单纯的制霉菌素阴道上药治疗,剂量及用法同联合组,两组均连用10d。观察并记录两组治疗后的临床效果,并比较两组不良妊娠结局。结果治疗结束后1个月,在临床总有效率方面联合组患者明显优于对照组(92.65%vs 80.88%)(χ2=4.10,P<0.05);联合组患者在早产、胎膜早破和产褥病等不良妊娠结局发生率明显低于对照组(2.94%、4.41%、7.35%vs 11.76%、14.71%、19.12%)(χ2=3.89、4.17、4.10,P<0.05),两组新生儿黄疸和低体重儿等不良妊娠结局发生率方面比较差异无统计学意义(P>0.05)。结论乳酸菌阴道胶囊辅助治疗妊娠中晚期VVC的疗效较确切,能明显改善其临床症状及特征,对早产、胎膜早破和产褥病等不良妊娠结局具有良好的预防作用。
Objective To investigate the preventive effect of lactic acid bacteria vaginal capsule on adverse pregnancy outcomes in patients with vulvovaginal candidiasis (VVC) in the second trimester of pregnancy. Methods 136 patients with VVC in the second trimester of pregnancy were randomly divided into combined group and control group of 68 cases. The patients in the combined group were treated with lactic acid bacteria vaginal capsule (0.25g / night) and nystatin (500,000 IU / night) combined with vaginal drug treatment (the use of two drugs interval of 4 ~ 6h); patients in the control group were treated with nystatin vaginally Drug treatment, dosage and usage with the joint group, two groups were used in conjunction 10d. The clinical effects of the two groups were observed and recorded, and the adverse pregnancy outcomes were compared between the two groups. Results One month after the end of treatment, the combined group was significantly better than the control group (92.65% vs 80.88%) in the total effective rate (χ2 = 4.10, P <0.05) The incidence of adverse pregnancy outcomes such as puerperal was significantly lower than that of the control group (2.94%, 4.41%, 7.35% vs 11.76%, 14.71%, 19.12%) (χ2 = 3.89,4.17,4.10, P <0.05) There was no significant difference in the incidence of adverse pregnancy outcomes such as jaundice and low birth weight children (P> 0.05). Conclusions Lactobacillus vaginal capsule adjuvant treatment of VVC in the second trimester of pregnancy is more effective and can obviously improve its clinical symptoms and features. It has a good preventive effect on adverse pregnancy outcomes such as premature labor, premature rupture of membranes and puerperal.