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维生素K依赖凝血因子包括凝血酶原(凝血因子Ⅱ)及因子Ⅶ、Ⅸ、Ⅹ.它们在肝细胞内合成过程中需要维生素K的参与,肝细胞内的维生素K,在微粒体环氧化酶作用下转变成环氧化叶绿醌,又在微粒体还原酶作用下还原成维生素K,促使凝血酶原前身氨基酸即r羧基谷氨酸的合成,已知因子Ⅱ、Ⅶ、Ⅸ、X同样有这种氨基酸,而维生素K的作用就是促进凝血酶原前身进行羧基化转变成凝血酶原,同样也促进因子Ⅷ、Ⅸ、X的合成.如果维生素K由于某种原因,特别是由于和
Vitamin K-dependent coagulation factors include prothrombin (factor Ⅱ) and factor Ⅶ, Ⅸ, Ⅹ. They require the participation of vitamin K in the synthesis of hepatocytes, vitamin K in liver cells, microsomal cyclooxygenase Under the action of the conversion into epoxidized phylloquinone, but also in the role of microsomal reductase reduced to vitamin K, prothrombin prothrombin amino acid that leads to carboxymethyl glutamate synthesis, the known factor II, VII, IX, X also There is this amino acid, and the role of vitamin K is to promote the conversion of prothrombin predecessor carboxylation into prothrombin, also promote factor VIII, IX, X. If vitamin K for some reason, especially because of