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支气管哮喘(哮喘)是一种多因素异质性疾病，严重影响儿童的身心健康。对于其发病原因及机制的研究一直是学者们关注的重点。近年来，呼吸道合胞病毒、鼻病毒、肺炎支原体等病原体感染与哮喘的关系逐渐明确，但是百日咳与哮喘之间的关系尚不明确。有研究认为百日咳杆菌感染后可诱导IgE的产生、激活Th2细胞并诱导Th17免疫应答，加强中性粒细胞对气道的炎症浸润、促进气道重塑、破坏气道纤毛结构引起呼吸道微生态失衡而导致哮喘，也可能通过Toll样受体9途径抑制气道高反应。但也有研究认为百日咳感染与哮喘无关。为了更好地了解百日咳感染与哮喘的关系，本文通过检索近期的文献加以阐述，以期提高认识，合理防控哮喘的发生、发展。“,”Bronchial asthma (asthma) is a multifactorial heterogeneous disease that seriously affects the physical and mental health of children.Recently, many scholars focus on the cause and mechanism of asthma.It had been confirm that respiratory syncytial virus, rhinovirus, n Mycoplasma pneumoniae and some other pathogens were associated with asthma.However, the relationship between pertussis and asthma is unclear.Some studies have suggested that pertussis infection can induce the production of IgE, activate Th2 cells and induce the Th17 immune response, strengthen the inflammatory infiltration of neutrophils to the airways, promote airway remodeling, damage airway ciliated epithelium structure and causing respiratory system microecological imbalanceto contributeto the asthma.It may also possible inhibit airway hyperresponsiveness through the Toll-like receptor-9 pathway.However some studies have suggested that pertussis infection has nothing to do with asthma.So, to better understand the relationship between whooping cough and asthma, we reviewed the recent literature and explained it in this study in order to raise pediatrician′s awareness and control the occurrence and development of asthma.n