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从天然植物中发现多种抗致癌物和抗致突变物,可在多个环节干扰致癌过程,阻断癌症的发生。本文报道存在于天然植物中的羟桂皮酸衍生物邻香豆酸、对香豆酸、咖啡酸及香豆素对细菌SOS反应、大鼠肝微粒体脂质过氧化的体外抑制和对环磷酰胺致小鼠骨髓微核和精子畸形的影响。
From natural plants found in a variety of anti-carcinogens and anti-mutagens, can interfere in many aspects of carcinogenic processes, blocking the occurrence of cancer. In this paper, we report the in vitro inhibition of bacterial SOS by oxycinnamic acid derivatives of p-coumaric acid, p-coumaric acid, caffeic acid and coumarin, the inhibition of lipid peroxidation in rat liver microsomes and the inhibition of cyclophosphamide Effect of amide on micronuclei and sperm deformity in bone marrow of mice.