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早在六十年代初期,邹冈给动物脑室及脑内局部注射微量吗啡类制剂,发现能产生明显的镇痛效应,此效应能被纳洛酮所对抗,提示体内可能存在着与阿片类配基有特异性结合的阿片受休。1971年Goldstein用放射受体结合法证明脑内有特异性的阿片结合。1973年Simon,Snyder,Terenius三家不同实验室分别用高比活性的阿片配基证明了脑内阿片受体的存在。由此人们推想机体内应存在内源性的阿片样物质——阿片受体的天然配
As early as the early 1960s, Zou Gang injected morphine and morphine into the ventricles and brain of animals to find obvious analgesic effect. This effect can be antagonized by naloxone, suggesting that there may be some differences between the opioids Basal opioids with specific binding are off. In 1971 Goldstein proved that there was specific opioid binding in the brain using radioreceptor binding. In 1973, Simon, Snyder, Terenius three different laboratories with high specific activity of opioid ligand to prove the presence of opioid receptors. Therefore, people think that there should be the body’s endogenous opioid - opioid receptor natural distribution