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对63例接受顺铂和/或阿霉素联合化疗的患者进行了随机自身对照,观察康泉和枢复宁预防抗癌药物引起恶心、呕吐的效果。患者均在第一天给药。63例患者被随机分为A、B两组,均接受两个周期相同的化疗。A组第一周期用康泉止吐,第二周期用枢复宁止吐;B组第一周期用枢复宁止吐,第二周期用康泉止吐。结果表明:康泉第一天止吐的有效率为90.5％,平均呕吐为4次。枢复宁第一天止吐的有效率为82.3％,平均呕吐次数为4.6次。统计学两组无显著差异。对迟发性呕吐和毒性反应也进行对比,康泉与枢复宁也无明显差别。
Sixty-three patients who received cisplatin and/or doxorubicin combined with chemotherapy received randomized self-controls to observe the effects of Kangquan and Shufuning on preventing nausea and vomiting caused by anticancer drugs. Patients were given on the first day. Sixty-three patients were randomly divided into two groups, A and B, and received the same chemotherapy for two cycles. The first cycle of group A was treated with Kangquan antiemetic, and the second cycle was treated with shufuning syringa; the first cycle of group B was antiemetic with shufuning, and the second cycle was antiemetic with Kangquan. The results showed that the effective rate of Kangquan on the first day of antiemetic was 90.5% and the average vomiting was 4 times. The effective rate of antiemetic in the first day of shufuning was 82.3%, and the average number of vomiting was 4.6 times. There was no significant difference between the two groups in statistics. Delayed vomiting and toxicity were also compared, and there was no significant difference between Kangquan and Shufuing.