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用Ｗｉｓｔａｒ大鼠４条血管关闭的全脑缺血再灌注模型，观察脑缺血再灌注脑组织超氧化物歧化酶（ＳＯＤ）活性及丙二醛（ＭＤＡ）含量的变化及东菱克栓酶对它的影响。发现对照组脑组织ＭＤＡ含量（４９１．２０±４１．０１ｎｍｏｌ／ｇ脑湿重）及ＳＯＤ活性（９．１２±０．８２Ｕ／ｍｇ脑湿重）均高于假手术组的ＭＤＡ含量（３４９．４５±３２．７１ｎｍｏｌ／ｇ脑湿重）及ＳＯＤ活性（７．９９±０．３３Ｕ／ｍｇ脑湿重），Ｐ＜０．０１及（０．００１，而东菱克栓酶组的ＭＤＡ含量（４３７．９４±４７．８９ｎｍｏｌ／ｇ脑湿重）显著低于对照组（Ｐ＜０．０１），ＳＯＤ活性（９．０６±１．０８Ｕ／ｍｇ脑湿重）与对照组间的差异不显著。提示东菱克栓酶具有清除自由基、抗脂质过氧化作用。
To investigate the changes of superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in cerebral ischemia-reperfusion brain tissue in rats with global ischemia-reperfusion after 4-vessel occlusion in Wistar rats, Impact on it. It was found that MDA content (491.20 ± 41.01nmol / g brain wet weight) and SOD activity (9.12 ± 0.82U / mg brain wet weight) in the control group were higher than those in the sham operation group (P <0.01). 45 ± 32.71nmol / g brain wet weight) and SOD activity (7.99 ± 0.33U / mg wet weight), P <0.01 and (0.001, respectively) (437.94 ± 47.89nmol / g brain wet weight) was significantly lower than that of the control group (P <0.01), SOD activity (9.06 ± 1.08U / mg brain wet weight) and the control group Significantly, suggesting that Ling Tong Ke bolt enzyme with free radical scavenging, anti-lipid peroxidation.