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目的探讨胃镜钛夹止血联合肾上腺素注射液治疗非静脉曲张上消化道出血的临床效果。方法随机选取2010年2月至2014年2月非静脉曲张上消化道出血患者70例,依据治疗方案分为两组,每组35例。对照组给予胃镜注射肾上腺素治疗,观察组则给予胃镜钛夹止血联合肾上腺素注射液治疗,比较两组临床止血效果、出血死亡风险及不良反应发生率。结果治疗后,观察组术后及时止血率、有效止血率均高于对照组(97.1%比80.0%、91.4%比60.0%),且再出血率低于对照组(5.7%比25.7%),差异均有统计学意义(P<0.05)。治疗后观察组出血死亡风险低于对照组(1.1分比2.8分)。观察组不良反应率低于对照组(17.1%比80.0%),差异有统计学意义(P<0.05)。结论胃镜钛夹止血联合肾上腺素注射液治疗肺静脉曲张上消化道出血疗效显著,不良反应少,止血率高,出血死亡风险低,值得临床进一步推广。
Objective To investigate the clinical effect of endoscopic titanium clip and epinephrine injection in the treatment of non-variceal upper gastrointestinal bleeding. Methods Seventy patients with non-variceal upper gastrointestinal bleeding were randomly selected from February 2010 to February 2014. The patients were divided into two groups according to the treatment regimen, 35 cases in each group. The control group was treated with endoscopic injection of epinephrine, while the observation group was treated with endoscopic titanium clip and epinephrine injection. The clinical hemostatic effects, the risk of bleeding death and the incidence of adverse reactions were compared between the two groups. Results After treatment, the hemostatic rate and effective rate of hemostasis in the observation group were significantly higher than those in the control group (97.1% vs. 80.0%, 91.4% vs. 60.0%), and the rate of rebleeding was lower than that of the control group (5.7% vs 25.7%). The differences were statistically significant (P <0.05). After treatment, the bleeding risk of observation group was lower than that of control group (1.1 points vs 2.8 points). The adverse reaction rate in the observation group was lower than that in the control group (17.1% vs. 80.0%), with significant difference (P <0.05). Conclusions Endoscopic titanium clip hemostasis combined with epinephrine injection for the treatment of upper gastrointestinal bleeding varicose veins significant effect, less adverse reactions, high rate of hemostasis, the risk of bleeding death is low, it is worth further clinical promotion.