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目的探讨贝那普利联合美托洛尔治疗老年慢性心力衰竭患者的治疗效果。方法选取2014年1月至2015年12月在营口开发区中心医院治疗的老年慢性心力衰竭患者86例为研究对象,按随机数字表法分观察组与对照组,每组43例。对照组患者给予常规抗心力衰竭治疗,观察组患者在对照组的基础上给予贝那普利联合美托洛尔治疗。比较两组患者的左心室射血分数、左心室收缩末期内径、6 min内步行距离及不良反应发生情况。结果观察组患者的总有效率为95.3%,高于对照组的79.1%,差异有统计学意义(P<0.05);观察组患者左心室射血分数明显高于对照组、左心室收缩末期内径明显低于对照组、6 min内步行距离明显高于对照组,差异均有统计学意义(均P<0.05)。两组患者不良反应发生情况差异无统计学意义(P>0.05)。结论贝那普利联合美托洛尔治疗老年慢性心力衰竭能显著提高患者的治疗效果,促进心功能恢复,缓解心力衰竭症状,且不良反应少。
Objective To investigate the therapeutic effect of benazepril combined with metoprolol in elderly patients with chronic heart failure. Methods A total of 86 elderly patients with chronic heart failure who were treated in Central Hospital of Yingkou Development Zone from January 2014 to December 2015 were selected as the research object. According to random number table, the observation group and the control group were divided into observation group and control group with 43 cases in each group. Patients in the control group were given conventional anti-heart failure treatment. Patients in the observation group were treated with benazepril combined with metoprolol on the basis of the control group. Left ventricular ejection fraction, left ventricular end-systolic diameter, walking distance within 6 min and adverse reactions were compared between the two groups. Results The total effective rate in observation group was 95.3%, which was higher than that in control group (79.1%), the difference was statistically significant (P <0.05); the left ventricular ejection fraction in observation group was significantly higher than that in control group, Significantly lower than the control group, walking distance within 6 min was significantly higher than the control group, the difference was statistically significant (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion The combination of benazepril and metoprolol in the treatment of elderly patients with chronic heart failure can significantly improve the therapeutic effect of the patients, promote the recovery of cardiac function and relieve the symptoms of heart failure, with less adverse reactions.