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[目的]评价LETP方案治疗复发性大肠癌的疗效和毒副作用。[方法]经手术或病理学证实为复发性大肠癌患者48例均采用吡喃阿霉素(THP)35mg/m2静滴d1,顺铂(DDP)20mg/m2静滴d1～5,亚叶酸钙(LV)200mg/m2静滴d1～5;5-氟脲嘧啶(5-Fu)500mg/m2静滴d1～5。21d为1个周期,所有患者均连续治疗2个周期或2个周期以上。[结果]48例中CR2例(4.17%),PR14例(29.17%),PD4例(8.33%),总有效率为33.34%。主要毒副反应为骨髓抑制和胃肠道反应,无化疗相关性死亡。[结论]LETP方案治疗复发性大肠癌疗效较好,毒副反应尚可耐受。
[Objective] To evaluate the efficacy and side effects of LETP regimen in the treatment of recurrent colorectal cancer. [Method] Forty-eight patients with recurrent colorectal cancer confirmed by operation or pathology were treated with 35 mg / m2 of pirarubicin (THP), d1 ~ 20 mg / m2 of intravenous infusion of dl- Calcium (LV) 200mg / m2 infusion d1 ~ 5; 5-fluorouracil (5-Fu) 500mg / m2 infusion d1 ~ 5.21d for a cycle, all patients were treated for 2 cycles or 2 cycles the above. [Results] The total effective rate was 33.34% in 48 cases of CR2 (4.17%), PR14 (29.17%) and PD (8.33%). The main toxicities were myelosuppression and gastrointestinal reactions, with no chemotherapy-related deaths. [Conclusion] The LETP regimen is effective in treating recurrent colorectal cancer with tolerable side effects.