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垂体肿瘤为颅内常见肿瘤之一,目前,对垂体肿瘤发病机理的研究主要集中在两个方面:一是垂体肿瘤起源于异常生理调节的结果(由于靶腺负反馈调节的丧失或丘脑下部异常的正向调节而导致过度刺激增生);二是垂体肿瘤起源于癌基因的激活或抑癌基因的丧失。随着分子生物学技术的进展,人们发现垂体生长激素(GH)腺瘤与G蛋白功能变异有关,从而对其发病机理和内分泌特征有了更深的认识。 一、G蛋白及其偶联的信号转运 G蛋白即鸟嘌呤核苷酸结合蛋白,是由α、β、γ三种亚基组成的三聚体家族,每一亚基又含有许多成员。它位于细胞膜的内侧面,其α亚基能结合鸟嘌呤
Pituitary tumor is one of the common intracranial tumors. At present, the research on the pathogenesis of pituitary tumors mainly focuses on two aspects: First, the pituitary tumor originates from the results of abnormal physiological regulation (due to loss of target gland negative feedback regulation or abnormal hypothalamus Positive regulation leads to hyperstimulation of hyperplasia. Second, pituitary tumors originate from oncogene activation or loss of tumor suppressor genes. With advances in molecular biology technology, it has been found that pituitary growth hormone (GH) adenomas are associated with G protein function mutations, and thus have a deeper understanding of its pathogenesis and endocrine characteristics. First, the G protein and its coupled signal transport G protein guanine nucleotide binding protein, is composed of three subunits of α, β, γ trimeric family, each subunit contains many members. It is located on the inner surface of the cell membrane and its α subunit binds guanine.