Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induce

• 作 者: Chinnadurai Veeramani Khalid S Al-Numair Mohammed A Alsaif Govindasamy Chandramohan Nouf S Al-Numair Kodukkur Viswanathan Pugalendi
• 机 构: Department of Community Health Sciences,College of Applied Medical Sciences,King Saud University,Dep
• 出 处: Asian Pacific Journal of Tropical Medicine
• 发表日期: 2012年12期
• 关键词: glycoprotein administration protective metabolism streptozotocin alteration alte

Objective:To investigate the protective role of Cardiospermum halicacabum(C.halicacabum) leaf extract on glycoprotein metabolism in streptozotocin(STZ)-induced diabetic rats.Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ.The C.halicacabum leaf extract(CHE) was administered orally to normal and STZ-diabetic rats for 45 days.The effects of C.halicacabum leaf extract(CHE) on plasma and tissue glycoproteins (hexose,hexosamine,fucose and sialic acid) were determined.Results:The levels of plasma and tissues glycoproteins containing hexose,hexosamine and fucose were significantly increased in STZ-induced diabetic rats.In addition,the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats.After administration of CHE to diabetic rats,the metabolic alteration of glycoprotein reverted towards normal levels. Conclusions:The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.

Objective: To investigate the protective role of Cardiospermum halicacabum (C. halicacabum) leaf extract on glycoprotein metabolism in streptozotocin (STZ) -induced diabetic rats. Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ. C. chalicacum leaf extracts (CHE) was administered orally to normal and STZ-diabetic rats for 45 days. The effects of C. halicacabum leaf extract (CHE) on plasma and tissue glycoproteins were confirmed. Results: The levels of plasma and tissues glycoproteins containing hexose, hexosamine and fucose were significantly increased in STZ-induced diabetic rats. In addition, the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats. After administration of CHE to diabetic rats, the metabolic alteration of glycoprotein reverted towards normal levels. Conclusions: The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.