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【目的】探讨2型糖尿病肾病（DN）患者临床分期与骨质疏松及生长因子的关系。【方法】在本院接受治疗的200例2型糖尿病DN患者（观察组），根据尿白蛋白排泄率（UAE）将患者分为A组（正常白蛋白尿，UAE200 μg/min）及D组［终末期肾衰竭，肾小球滤过率(GFR) <10 mL/min］。选取同期本院健康体检者50例作为对照组。观察研究对象骨质疏松及生长因子相关指标水平。【结果】观察组松质骨骨密度及骨矿含量、皮质骨骨密度及骨矿含量均低于对照组（P均＜0.05），松质骨T值及皮质骨T值均高于对照组（P均＜0.05）。观察组各亚组间骨密度及生长因子指标相比较差异均有显著性（P＜0.05）；D组松质骨骨密度及骨矿含量、皮质骨骨密度及骨矿含量低于A、B、C组，松质骨T值及皮质骨T值高于A、B、C组（均P＜0.05）。观察组成纤维细胞生长因子-23（FGF-23）、白细胞介素-6（IL-6）水平高于对照组，胰岛素样生长因子-Ⅱ（IGF-Ⅱ）、表皮生长因子（EGF）、转化生长因子-β（TGF-β）低于对照组（均P＜0.05）。D组FGF-23、IL-6高于A、B、C组，IGF-Ⅱ、EGF、TGF-β低于A、B、C组（均P＜0.05）；C组FGF-23、IL-6高于A、B组，IGF-Ⅱ、EGF、TGF-β低于C组（均P＜0.05）。【结论】2型糖尿病DN患者病情严重程度与骨质疏松及生长因子密切相关，DN患者骨质疏松的发生可能与生长因子相关。|%【Objective】To investigate the relationship of clinical stage with osteoporosis and growth factors in patients with type 2 diabetic nephropathy (DN). 【Methods】A total of 200 patients with type 2 diabetic nephropathy, who received treatment in our hospital, were selected as the observation group. According to the value of albumin excretion rate (UAE), patients were divided into group A (normal albuminuria, UAE200 μg/min) and group D (end-stage renal failure, GFR <10 mL/min). In the same time period, 50 healthy volunteers were enrolled as the control group. The levels of osteoporosis and growth factor-related indicators were evaluated. 【Results】The bone mineral density and mineral content of both cancellous and cortical bones in the observation group were lower than those in the control group (P<0.05). The T value of the cancellous bone and the cortical bone were higher than those of the control group (P<0.05). There were significant differences in bone mineral density and growth factor indicators among the subgroups of the observation group (P<0.05). The cancellous and cortical bone mineral density and mineral content in group D were lower than those in group A, B and C, while the T value of the cancellous bone and the cortical bone were higher than those in group A, B and C (P<0.05). The levels of FGF-23 and IL-6 in the observation group were higher than those in the control group, and IGF-Ⅱ, EGF and TGF-βlevels were lower than those in the control group (P<0.05). The levels of FGF-23 and IL-6 in group D were higher than those in group A, B and C, and IGF-Ⅱ, EGF and TGF-βwere lower than those in group A, B and C (P<0.05). The levels of FGF-23 and IL-6 in group C were higher than those in group A and B, and IGF-Ⅱ, EGF and TGF-βwere lower than those in group A and B (P<0.05). 【Conclusion】The severity of DN in patients with type 2 diabetes is closely related to osteoporosis and growth factors. The occurrence of osteoporosis in DN patients may be related to growth factors.