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目的 :评价氯沙坦 (Los)与非洛地平 (Felo)治疗高血压病的临床疗效。方法 :采用随机、单盲、平行对照方法 ,将 6 0例轻、中度高血压患者均分成Los组 (30例 ) ,口服Los 5 0～ 10 0mg/d ,疗程 4周和Felo组 (30例 ) ,口服Felo 5～ 10mg/d ,疗程 4周。每周测诊室血压 (CBP)、心率 (HR) ,治疗前后行 2 4h动态血压监测 (ABPM )。 结果 :4周末Los组与Felo组总有效率分别为 80 .0 %与 83 .4% ,与治疗前比差异非常显著 (P <0 .0 1) ,组间比无显著性差异 (P >0 .0 5 )。动态血压测定 2 4h、日间、夜间血压均值较治疗前明显下降 (P <0 .0 1) ,Los略优于Felo。收缩压 (SBP)和舒张压 (DBP)的谷峰比值 (T/P)均大于 5 0 %。不良反应Felo多于Los。结论 :两种药物均不影响血压昼夜节律 ,降压谷峰比值较好 ,均为有前途的抗高血压药
Objective: To evaluate the clinical efficacy of losartan and felodipine in the treatment of hypertension. Methods: A total of 60 mild and moderate hypertensive patients were randomly divided into Los group (30 cases), Los (50 ~ 100 mg / d), 4 weeks treatment and Felo group (30 Cases), oral Felo 5 ~ 10mg / d, treatment for 4 weeks. Weekly test room blood pressure (CBP), heart rate (HR), 24 h before and after treatment of ambulatory blood pressure monitoring (ABPM). Results: The total effective rates of Los group and Felo group were 80.0% and 83.4% at the end of 4 weeks respectively, which were significantly different from those before treatment (P <0.01), there was no significant difference between the two groups (P> 0 .0 5). Ambulatory blood pressure 2 4h, daytime and nighttime mean blood pressure was significantly lower than before treatment (P <0. 01), Los slightly better than Felo. SBP and DBP peak to trough ratio (T / P) were more than 50%. Adverse reactions Felo more than Los. Conclusion: The two drugs did not affect the circadian rhythm of blood pressure, blood pressure peak trough ratio is better, are promising antihypertensive drugs