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报道了用Ｘ－５树脂固相萃取分离纯化、ＧＣ－ＦＩＤ和ＧＣ－ＭＳ定量和定性分析血浆中巴比妥类药物的方法，含药物的血浆可直接用萃柱处理，操作简单方便，用甲醇－乙酸乙酯作为洗脱剂，不同药物的相对回收率为９５～１０５．４％，ＲＳＤ为３．４６～６．４１％。检测灵敏度及线性范围适合血药浓度的监测及中毒急救分析的需要。
A method for the quantitative and qualitative analysis of barbiturates in plasma by GC-FID and GC-MS has been reported. The drug-containing plasma can be directly treated with extraction column. The operation is simple and convenient. Methanol - ethyl acetate as eluent, the relative recovery of different drugs was 95 ~ 105.4%, RSD was 3.46 ~ 6.41%. Sensitivity and linearity of detection are suitable for the monitoring of blood concentration and the need of first aid analysis of poisoning.