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摘要目的前瞻性评估奥沙利铂联合5-氟尿嘧啶经肝动脉灌注化疗治疗进展期肝门区胆管癌的有效性及安全性。材料与方法本研究经伦理委员会批准,所有病人均签署知情同意。本研究主要纳入无法切除的肝门部胆管癌病人,并经门静脉插管进行灌注化疗。肝动脉灌注化疗方案:于每3~4周的第1~3 d注入奥沙利铂40 mg/m~2 2 h,随后连续注入5-氟尿嘧啶800 mg/m~2共22 h。为控制肿瘤该方案连续应
Abstract Objective To prospectively evaluate the efficacy and safety of oxaliplatin combined with 5-fluorouracil in hepatic artery perfusion chemotherapy in the treatment of advanced hilar cholangiocarcinoma. Materials and Methods The study was approved by Ethics Committee and all patients signed informed consent. This study mainly involved patients with unresectable hilar cholangiocarcinoma and was infused via portal vein catheterization. Hepatic arterial infusion chemotherapy regimen: Oxaliplatin 40 mg / m ~ 2 2 h was injected every 3 to 4 weeks from 1 to 3 d, followed by continuous injection of 5-fluorouracil 800 mg / m 2 for 22 h. The program should be continued for the control of tumors