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目的分析宁波市鄞州区2012年-2013年手足口病的病原谱,为本区手足口病防治提供科学依据。方法对手足口病病例标本进行肠道病毒通用型(EV)、肠道病毒71型(EV71)、柯萨奇病毒A16型(CA16)和柯萨奇病毒A6型(CA6)核酸检测。结果 2012年4个季度EV71占同季度阳性病例的比率分别为31.6%、28.9%、33.3%、21.8%;2013年EV71占同季度阳性病例的比率分别为19.4%、15.7%、2.4%、11.1%。2012年4个季度CA16占同季度阳性病例的比率分别为50.9%、40.2%、26.2%、3.2%;2013年全年检出14例。2012年第2季度开始检出CA6,至第4季度占阳性病例数的62.9%;2013年CA6分别占同季度阳性病例数的75.0%、48.2%、56.1%、59.1%。结论 2012年前3季度本区手足口病病原主要为EV71和CA16。2012年第4季度至2013年,CA6替代EV71和CA16成为本地手足口病的主要病原。
Objective To analyze the pathogen spectrum of HFMD in Yinzhou District of Ningbo City from 2012 to 2013 and provide scientific evidences for the prevention and treatment of HFMD in this area. Methods The samples of hand, foot and mouth disease were tested for EV, EV71, C16 and Coxsackie virus A6 (CA6). Results The rates of EV71 in the four quarters of 2012 were 31.6%, 28.9%, 33.3% and 21.8% respectively in the same quarter of 2012. The rates of EV71 in the same quarter in 2013 were 19.4%, 15.7%, 2.4% and 11.1 %. In the fourth quarter of 2012, the proportion of CA16 in the same quarter of 2012 was 50.9%, 40.2%, 26.2% and 3.2% respectively. In 2013, 14 cases were detected. CA6 was detected in the second quarter of 2012, accounting for 62.9% of the positive cases in the fourth quarter. In 2013, CA6 accounted for 75.0%, 48.2%, 56.1% and 59.1% of the positive cases in the same quarter respectively. Conclusions In the first three quarters of 2012, the pathogens of HFMD in this area are mainly EV71 and CA16. From the fourth quarter of 2012 to 2013, the CA6 alternative EV71 and CA16 are the main pathogens of local hand-foot-mouth disease.