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应用单克隆抗体及SABC免疫组化技术,随机观察39例肾活检组织,结果发现肾炎组织内浸润的细胞主要为DR抗原阳性活化的T_4~+、T_8~+细胞,且其数量、分布方式和部位及DR抗原在肾小管上皮细胞的异常表达均与肾小球硬化、新月体形成及肾小管损伤关系密切。这些结果提示肾炎肾组织病变的发生可能系细胞免疫和肾小管上皮细胞的主动参与所致。
39 cases of renal biopsies were observed by monoclonal antibody and SABC immunohistochemistry. The results showed that the infiltrating cells in nephritic tissues were predominantly T_4 ~ +, T_8 ~ + cells activated by DR antigen, and the number, distribution and The abnormal expression of DR and DR in renal tubular epithelial cells were closely related to glomerulosclerosis, crescent formation and renal tubular injury. These results suggest that the occurrence of nephritis and renal tissue lesions may be due to cellular immunity and the active participation of renal tubular epithelial cells.